Age-related changes in the response of retinal structure, function and blood flow to pressure modification in rats
Da Zhao, Christine TO Nguyen, Zheng He, Vickie HY Wong, Anna K van Koeverden, Algis J Vingrys, Bang V Bui
SCIENTIFIC REPORTS | NATURE PUBLISHING GROUP | Published : 2018
Age-related changes to the balance between the pressure inside the eye (intraocular pressure, IOP) and the pressure inside the brain (intracranial pressure, ICP) can modify the risk of glaucoma. In this study, we consider whether the optic nerve in older rat eyes is more susceptible to acute IOP and ICP modification. We systematically manipulate both ICP and IOP and quantify their effects on ganglion cell function (electroretinography, ERG), optic nerve structure (optical coherence tomography, OCT) and retinal blood flow (Doppler OCT). We show that ganglion cell function in older eyes was more susceptible to a higher optic nerve pressure difference (ONPD = IOP - ICP). This age-related suscep..View full abstract
Related Projects (3)
Awarded by Australian National Health and Medical Research Council
Awarded by Australian Research Council (ARC) Future Fellowship Award
This research was supported by: an Australian Research Council (ARC) Future Fellowship Award (FT130100388), Australian National Health and Medical Research Council (1046203) project grant.