A comprehensive meta-analysis of circulation miRNAs in glioma as potential diagnostic biomarker
Chenkai Ma, Hong PT Nguyen, Rodney B Luwor, Stanley S Stylli, Andrew Gogos, Lucia Paradiso, Andrew H Kaye, Andrew P Morokoff
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2018
Glioma is the most common malignant intracranial tumour. Recently, several publications have suggested that miRNAs can be used as potential diagnostic biomarkers of glioma. Here we performed a meta-analysis to identify the diagnostic accuracy of differentially expressed circulating miRNAs in gliomas. Using PubMed, Medline and Cochrane databases, we searched for studies which evaluated a single or panel of miRNAs from circulating blood as potential biomarkers of glioma. Sixteen publications involving 23 studies of miRNAs from serum or plasma met our criteria and were included in this meta-analysis. The pooled diagnostic parameters were calculated by random effect models and overall diagnostic..View full abstract
We would like to acknowledge the Cure Brain Cancer Foundation, the Royal Melbourne Hospital Neuroscience Foundation for their funding support to Dr A.Morokoff and Melbourne International Research Scholarship to Mr C.Ma, and the Victorian Government for Infrastructure support.We would like to acknowledge the support of the Cure Brain Cancer Foundation, the Royal Melbourne Hospital Neuroscience Foundation (Dr A Morokoff) and The University of Melbourne International Research Scholarship (Dr C Ma).