Journal article
Advances in kinome research of parasitic worms - implications for fundamental research and applied biotechnological outcomes
AJ Stroehlein, ND Young, RB Gasser
Biotechnology Advances | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2018
Abstract
Protein kinases are enzymes that play essential roles in the regulation of many cellular processes. Despite expansions in the fields of genomics, transcriptomics and bioinformatics, there is limited information on the kinase complements (kinomes) of most eukaryotic organisms, including parasitic worms that cause serious diseases of humans and animals. The biological uniqueness of these worms and the draft status of their genomes pose challenges for the identification and classification of protein kinases using established tools. In this article, we provide an account of kinase biology, the roles of kinases in diseases and their importance as drug targets, and drug discovery efforts in key so..
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Funding Acknowledgements
Research funding from the National Health and Medical Research Council of Australia (NHMRC), Australian Research Council (ARC), Australia and Wellcome Trust, UK, is gratefully acknowledged (R.B.G.). Support from the Australian Academy of Science, Australia, the Australian-American Fulbright Commission, Australia, Alexander von Humboldt Foundation, Germany, Melbourne Water Corporation, Australia as well as the Melbourne Bioinformatics Platform, Australia, and WormBase (www.wormbase.org) is gratefully acknowledged. N.D.Y. is an NHMRC Career Development Fellow. The authors are very grateful for the constructive reports from anonymous reviewers.