Journal article

Elevated Blood Viscosity and Microrecirculation Resulting From Coronary Stent Malapposition

Eric KW Poon, Vikas Thondapu, Umair Hayat, Peter Barlis, Chooi Yin Yap, Po-Hung Kuo, Qisen Wang, Jiawei Ma, Shuang J Zhu, Stephen Moore, Andrew SH Ooi

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME | ASME | Published : 2018

Abstract

One particular complexity of coronary artery is the natural tapering of the vessel with proximal segments having larger caliber and distal tapering as the vessel get smaller. The natural tapering of a coronary artery often leads to proximal incomplete stent apposition (ISA). ISA alters coronary hemodynamics and creates pathological path to develop complications such as in-stent restenosis, and more worryingly, stent thrombosis (ST). By employing state-of-the-art computer-aided design software, generic stent hoops were virtually deployed in an idealized tapered coronary artery with decreasing malapposition distance. Pulsatile blood flow simulations were carried out using computational fluid d..

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Grants

Awarded by Australian Research Council


Awarded by Victorian Life Sciences Computation Initiative (VLSCI) on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government, Australia


Funding Acknowledgements

Australian Research Council through ARC Linkage Project (Grant No. LP150100233).A Victorian Life Sciences Computation Initiative (VLSCI) (Grant No. VR0210) on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government, Australia.