Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain A beta-amyloid burden
Stephanie R Rainey-Smith, Gavin N Mazzucchelli, Victor L Villemagne, Belinda M Brown, Tenielle Porter, Michael Weinborn, Romola S Bucks, Lidija Milicic, Hamid R Sohrabi, Kevin Taddei, David Ames, Paul Maruff, Colin L Masters, Christopher C Rowe, Olivier Salvado, Ralph N Martins, Simon M Laws
Translational Psychiatry | NATURE PUBLISHING GROUP | Published : 2018
The glymphatic system is postulated to be a mechanism of brain Aβ-amyloid clearance and to be most effective during sleep. Ablation of the astrocytic end-feet expressed water-channel protein, Aquaporin-4, in mice, results in impairment of this clearance mechanism and increased brain Aβ-amyloid deposition, suggesting that Aquaporin-4 plays a pivotal role in glymphatic function. Currently there is a paucity of literature regarding the impact of AQP4 genetic variation on sleep, brain Aβ-amyloid burden and their relationship to each other in humans. To address this a cross-sectional observational study was undertaken in cognitively normal older adults from the Australian Imaging, Biomarkers and ..View full abstract
Awarded by Co-operative Research Centre (CRC) for Mental Health
Funding for the AIBL study was provided in part by the study partners (Commonwealth Scientific Industrial and Research Organization (CSIRO), Edith Cowan University (ECU), Mental Health Research institute (MHRI), National Ageing Research Institute (NARI), Austin Health, CogState Ltd.). The AIBL study has also received support from the National Health and Medical Research Council (NHMRC) and the Dementia Collaborative Research Centres program (DCRC2), as well as funding from the Science and Industry Endowment Fund (SIEF) and the Co-operative Research Centre (CRC) for Mental Health-funded through the CRC Program (Grant ID: 20100104), an Australian Government Initiative. We thank all those who took part as subjects in the study for their commitment and dedication to helping advance research into the early detection and causation of AD.