Journal article

Rescue of Premature Coronal Suture Fusion With TGF-beta 2 Neutralizing Antibody in Rabbits With Delayed-Onset Synostosis

Mark P Mooney, Jocelyn M Shand, Anne Burrows, Timothy D Smith, John F Caccamese, Gregory M Cooper, James J Cray, James Gilbert, Bernard J Costello, Joseph E Losee, Amr M Moursi, Michael I Siegel

The Cleft Palate-Craniofacial Journal | ALLIANCE COMMUNICATIONS GROUP DIVISION ALLEN PRESS | Published : 2018

Abstract

OBJECTIVES: An overexpression of Tgf-β2 leads to calvarial hyperostosis and suture fusion in individuals with craniosynostosis. Inhibition of Tgf-β2 may help rescue fusing sutures and restore normal growth. The present study was designed to test this hypothesis. DESIGN: Twenty-eight New Zealand White rabbits with delayed-onset coronal synostosis had radiopaque markers placed on either side of the coronal sutures at 10 days of age. The rabbits were randomly assigned to: (1) sham control rabbits (n = 10), (2) rabbits with control IgG (100 μg/suture) delivered in a collagen vehicle (n = 9), and (3) rabbits with Tgf-β2 neutralizing antibody (100 μg/suture) delivered in a collagen vehicle (n = 9)..

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