Journal article
Native Myocardial T1 Mapping by Cardiovascular Magnetic Resonance Imaging in Subclinical Cardiomyopathy in Patients With Systemic Lupus Erythematosus
Valentina O Puntmann, David D'Cruz, Zachary Smith, Ana Pastor, Peng Choong, Tobias Voigt, Gerry Carr-White, Shirish Sangle, Tobias Schaeffter, Eike Nagel
CIRCULATION-CARDIOVASCULAR IMAGING | LIPPINCOTT WILLIAMS & WILKINS | Published : 2013
Abstract
BACKGROUND: Increased systemic inflammation has been linked to myocardial dysfunction and heart failure in patients with systemic lupus erythematosus (SLE). Accurate detection of early myocardial changes may be able to guide preventive intervention. We investigated whether multiparametric imaging by cardiovascular magnetic resonance can detect differences between controls and asymptomatic SLE patients. METHODS AND RESULTS: A total of 33 SLE predominantly female patients (mean age, 40±9 years) underwent cardiovascular magnetic resonance for routine assessment of myocardial perfusion, function, and late gadolinium enhancement. T1 mapping was performed in single short-axis slice before and afte..
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Funding Acknowledgements
Funding was received from the Department of Health via the National Institute for Health Research Comprehensive Biomedical Research Center award to Guy's and St. Thomas' National Health Service Foundation Trust in partnership with King's College London and King's College Hospital NHS Foundation Trust. Dr Pastor was supported by the Spanish Society of Cardiology.