Journal article

Unilateral Radiotherapy Treatment for p16/Human Papillomavirus-Positive Squamous Cell Carcinoma of Unknown Primary in the Head and Neck

Albert Tiong, Danny Rischin, Richard J Young, Alan Herschtal, Ben Solomon, Ieta D'Costa, Tsien Fua, Chen Liu, Andrew Coleman, Stephen Kleid, Benjamin J Dixon, June Corry

LARYNGOSCOPE | WILEY | Published : 2018


OBJECTIVES/HYPOTHESIS: The outcomes of unilateral radiotherapy treatment for patients with p16/HPV-positive squamous cell carcinomas of unknown primary (SCCUP) affecting cervical lymph nodes are under-reported. Compared to radiating large volumes of the pharyngeal axis (the more common approach), this is potentially a much less toxic treatment for a good prognosis group. STUDY DESIGN: Retrospective cohort study. METHODS: We identified patients with SCCUP who were treated radically at our center and did not have parotid or isolated level IV or V nodal involvement. Failure-free and overall survivals were calculated using Kaplan-Meier methods. RESULTS: From 2004 to 2012, there were 49 radically..

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