Thrombolysis in Acute Stroke Pooling Project: a meta-analysis on individual patient data

Abstract

To assess the efficacy and safety of thrombolytic therapy in acute ischaemic stroke, randomised clinical trials have been undertaken. Their results suggest that further research should be attempted to identify patients for whom the benefit/risk ratio of thrombolysis is beneficial. The Thrombolysis in Acute Stroke Pooling Project (TAS-PP) group will pool individual patient data from recent studies and meta-analyse these. A Steering Committee drafted the protocol and defined access rules to the common file. The objectives are to assess the efficacy of thrombolysis to reduce death or severe disability, to identify predictors of death and haemorrhagic transformation, and to identify subgroups wi..