Longitudinal association of type 1 interferon-induced chemokines with disease activity in systemic lupus erythematosus
KL Connelly, R Kandane-Rathnayake, M Huq, A Hoi, M Nikpour, EF Morand
SCIENTIFIC REPORTS | NATURE PUBLISHING GROUP | Published : 2018
Type I interferon (IFN) pathways are significant in SLE pathogenesis. Less is known about the utility of measuring markers of IFN activity in patients, or whether patient subsets with different profiles exist. We explored the longitudinal associations of IFN-induced chemokines with disease activity in a cohort of SLE patients. We calculated a validated composite score (IFN-CK) of three type I IFN-inducible chemokines (CCL2/CXCL10/CCL19) measured in 109 SLE patients (median 7 occasions over 3.2 years). Longitudinal associations of IFN-CK score with disease activity (SLEDAI-2K) and other variables were assessed using general estimating equation (GEE) methods. IFN-CK was detectable in all patie..View full abstract
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EFM and MN have received research grants from the National Health and Medical Research Council of Australia. EFM has received research support from Astra-Zeneca, Pfizer, Bristol-Myers Squibb, Janssen, UCB, CSL, and GSK. MN has received research support from Actelion, Bayer, CSL Biotherapies, GlaxoSmithKline and Pfizer.