Journal article
"Breathing" vesicles
S Yu, T Azzam, I Rouiller, A Eisenberg
Journal of the American Chemical Society | AMER CHEMICAL SOC | Published : 2009
DOI: 10.1021/ja902869q
Abstract
A vesicle system is described that possesses a pH-induced "breathing" feature and consists of a three-layered wall structure. The "breathing" feature consists of a highly reversible vesicle volume change by a factor of ca. 7, accompanied by diffusion of species into and out of the vesicles with a relaxation time of ca. 1 min. The triblock copolymer poly(ethylene oxide)45-block-polystyrene130-block-poly(2- diethylaminoethyl methacrylate)120 (PEO45-b-PS 130-b-PDEA120) was synthesized via ATRP. Self-assembly into vesicles was carried out at a pH of ca.10.4. The vesicle wall was shown by cryo-TEM to consist of a sandwich of two external ca. 4 nm thick continuous PS layers and one ca. 17 nm thick..
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Awarded by NSERC Canada
Awarded by CIHR
Funding Acknowledgements
It is of great pleasure for A.E. and S.Y. to acknowledge financial support from NSERC Canada (grant number RGPIN 4565-04) and for IR funding from CIHR (grant number MOP-86693) as well as the receipt of a CIHR New Investigator award.