Journal article
Metal-nucleic acid cages
H Yang, CK McLaughlin, FA Aldaye, GD Hamblin, AZ Rys, I Rouiller, HF Sleiman
Nature Chemistry | NATURE PUBLISHING GROUP | Published : 2009
DOI: 10.1038/nchem.290
Abstract
Metal-nucleic acid cages are a promising new class of materials.Like metallo-supramolecular cages, these systems can use their metals for redox, photochemical, magnetic and catalytic control over encapsulated cargo. However, using DNA provides the potential to program pore size, geometry, chemistry and addressability, and the ability to symmetrically and asymmetrically position transition metals within the three-dimensional framework. Here we report the quantitative construction of metal-DNA cages, with the site-specific incorporation of a range of metals within a three-dimensional DNA architecture. Oligonucleotide strands containing specific environments suitable for transition-metal coordi..
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Funding Acknowledgements
The authors thank NSERC, CFI, CSACS, CIHR and CIFAR for financial support, Jean-Pierre Sauvage for helpful discussion and J. Hedberg for help in preparing graphical illustrations. I. R. is recipient of a CIHR New Investigator award. G. D. H. thanks McGill University for a Tomlinson fellowship and C. K. M. thanks CIHR for a Chemical Biology scholarship. H. F. S. is a Cottrell Scholar of the Research Corporation.