Journal article
Vitamin D supplementation to prevent acute respiratory tract infections: Systematic review and meta-analysis of individual participant data
AR Martineau, DA Jolliffe, RL Hooper, L Greenberg, JF Aloia, P Bergman, G Dubnov-Raz, S Esposito, D Ganmaa, AA Ginde, EC Goodall, CC Grant, CJ Griffiths, W Janssens, I Laaksi, S Manaseki-Holland, D Mauger, DR Murdoch, R Neale, JR Rees Show all
BMJ Online | BMJ PUBLISHING GROUP | Published : 2017
DOI: 10.1136/bmj.i6583
Open access
Abstract
Objectives To assess the overall effect of vitamin D supplementation on risk of acute respiratory tract infection, and to identify factors modifying this effect. Design Systematic review and meta-analysis of individual participant data (IPD) from randomised controlled trials. Data sources Medline, Embase, the Cochrane Central Register of Controlled Trials, Web of Science, ClinicalTrials.gov, and the International Standard Randomised Controlled Trials Number registry from inception to December 2015. Eligibility criteria for study selection Randomised, double blind, placebo controlled trials of supplementation with vitamin D3 or vitamin D2 of any duration were eligible for inclusion if they ha..
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Awarded by National Heart, Lung, and Blood Institute
Funding Acknowledgements
This study was supported by a grant from the National Institute for Health Research (NIHR) under its Health Technology Assessment programme (reference No 13/03/25, to ARM). The views expressed are those of the authors and not necessarily those of the National Health Service, the NIHR, or the Department of Health. See the supplementary material for details of sources of support for individual investigators and trials. The NIHR was not involved in the study design; in the collection, analysis, or interpretation of data; in the writing of the report; or in the decision to submit the paper for publication.