Journal article
The NEAT domain-containing proteins of clostridium perfringens bind heme
JM Choo, JK Cheung, JA Wisniewski, DL Steer, DM Bulach, TJ Hiscox, A Chakravorty, A Ian Smith, DA Gell, JI Rood, MM Awad
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2016
Open access
Abstract
The ability of a pathogenic bacterium to scavenge iron from its host is important for its growth and survival during an infection. Our studies on C. perfringens gas gangrene strain JIR325, a derivative of strain 13, showed that it is capable of utilizing both human hemoglobin and ferric chloride, but not human holo-Transferrin, as an iron source for in vitro growth. Analysis of the C. perfringens strain 13 genome sequence identified a putative heme acquisition system encoded by an iron-regulated surface gene region that we have named the Cht (Clostridium perfringens heme transport) locus. This locus comprises eight genes that are co-Transcribed and includes genes that encode NEAT domain-cont..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by the Australian National Health and Medical Research Council (Project Grant GNT1005991) (https://www.nhmrc.gov.au/). Jocelyn M. Choo was the recipient of a Monash Graduate Scholarship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.We acknowledge the Australian National Health and Medical Research Council for supporting this work (Project Grant GNT1005991). Jocelyn M. Choo was the recipient of a Monash Graduate Scholarship.