Journal article
West Nile virus RNA not detected in urine of 40 people tested 6 years after acute West Nile virus disease
KB Gibney, RS Lanciotti, JJ Sejvar, CT Nugent, JM Linnen, MJ Delorey, JA Lehman, EN Boswell, JE Staples, M Fischer
Journal of Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2011
Abstract
West Nile virus (WNV) causes an acute infection that is usually cleared by an effective immune response after several days of viremia. However, a recent study detected WNV RNA in the urine of 5 of 25 persons (20%) tested several years after their initial acute WNV disease. We evaluated an established cohort of 40 persons >6 years after initial infection with WNV. Urine collected from all participants tested negative for WNV RNA by reversetranscription polymerase chain reaction and transcription-mediated amplification. Prospective studies are needed to determine if and for how long WNV persists in urine following WNV disease.
Grants
Funding Acknowledgements
This work was supported by the the Centers for Disease Control and Prevention.