Journal article

Characterisation and developmental potential of ovine bone marrow derived mesenchymal stem cells.

Rosa C McCarty, Stan Gronthos, Andrew C Zannettino, Bruce K Foster, Cory J Xian

Journal of Cellular Physiology | Published : 2009

Abstract

Since discovery, significant interest has been generated in the potential application of mesenchymal stem cells or multipotential stromal cells (MSC) for tissue regeneration and repair, due to their proliferative and multipotential capabilities. Although the sheep is often used as a large animal model for translating potential therapies for musculoskeletal injury and repair, the characteristics of MSC from ovine bone marrow have been inadequately described. Histological and gene expression studies have previously shown that ovine MSC share similar properties with human and rodents MSC, including their capacity for clonogenic growth and multiple stromal lineage differentiation. In the present..

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University of Melbourne Researchers