Journal article
Characterisation and developmental potential of ovine bone marrow derived mesenchymal stem cells
RC Mccarty, S Gronthos, AC Zannettino, BK Foster, CJ Xian
Journal of Cellular Physiology | WILEY | Published : 2009
DOI: 10.1002/jcp.21670
Abstract
Since discovery, significant interest has been generated in the potential application of mesenchymal stem cells or multipotential stromal cells (MSC) for tissue regeneration and repair, due to their proliferative and multipotential capabilities. Although the sheep is often used as a large animal model for translating potential therapies for musculoskeletal injury and repair, the characteristics of MSC from ovine bone marrow have been inadequately described. Histological and gene expression studies have previously shown that ovine MSC share similar properties with human and rodents MSC, including their capacity for clonogenic growth and multiple stromal lineage differentiation. In the present..
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Awarded by NHMRC
Funding Acknowledgements
The authors wish to thank Ms Jo Cool (Women's & Children's Hospital, South Australia) for her assistance in large animal surgery and tissue processing, Mr Tim Kuchel (IMVS, South Australia) and Ms Jodie Dier (IMVS) for bone marrow collection, Ms Lynn Scarman (WCH) for large animal coordination and assistance, and Bone Growth Foundation (BGF Australia) for providing The John Fitzgerald BGF PhD Scholarship (to RCM). This work is funded in part by NHMRC project grants (242804, 258700, 453443, and 453497) and funding from BGF.