Journal article
Antiplatelet therapy and the effects of B vitamins in patients with previous stroke or transient ischaemic attack: a post-hoc subanalysis of VITATOPS, a randomised, placebo-controlled trial
Graeme J Hankey, John W Eikelboom, Qilong Yi, Kennedy R Lees, Christopher Chen, Denis Xavier, Jose C Navarro, Udaya K Ranawaka, Wasim Uddin, Stefano Ricci, John Gommans, Reinhold Schmidt, Paolo Gresele
LANCET NEUROLOGY | ELSEVIER SCIENCE INC | Published : 2012
Abstract
BACKGROUND: Previous studies have suggested that any benefits of folic acid-based therapy to lower serum homocysteine in prevention of cardiovascular events might be offset by concomitant use of antiplatelet therapy. We aimed to establish whether there is an interaction between antiplatelet therapy and the effects of folic acid-based homocysteine-lowering therapy on major vascular events in patients with stroke or transient ischaemic attack enrolled in the vitamins to prevent stroke (VITATOPS) trial. METHODS: In the VITATOPS trial, 8164 patients with recent stroke or transient ischaemic attack were randomly allocated to double-blind treatment with one tablet daily of placebo or B vitamins (2..
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Awarded by Medical Research Council
Awarded by MRC
Funding Acknowledgements
The VITATOPS trial was funded by the National Health and Medical Research Council of Australia, the UK Medical Research Council, the Biomedical Research Council of Singapore, the National Medical Research Council of Singapore, the National Heart Foundation of Australia, the Royal Perth Hospital Medical Research Foundation, and the Health Department of Western Australia. Blackmores, Australia, supplied the B vitamin and matching placebo tablets.