Functionalized, Biocompatible Coating for Superparamagnetic Nanoparticles by Controlled Polymerization of a Thioglycosidic Monomer
Krzysztof Babiuch, Ralf Wyrwa, Kerstin Wagner, Thomas Seemann, Stephanie Hoeppener, C Remzi Becer, Ralf Linke, Michael Gottschaldt, Juergen Weisser, Matthias Schnabelrauch, Ulrich S Schubert
BIOMACROMOLECULES | AMER CHEMICAL SOC | Published : 2011
It is demonstrated that water-soluble, glucosylated poly(pentafluorostyrene) derivatives revealed favorable coating material properties for magnetic iron oxide nanoparticles. To prepare the coating material in high reproducibility and purity as well as in sufficient amounts, a new route of synthesis is established. The preparation and characterization of the glucosylated, tetrafluorostyryl monomer, by thiol-para-fluorine "click" reaction, and its polymerization, via nitroxide-mediated radical process, is presented in detail. In addition, the coating material and the resulting particle properties are investigated by means of XPS, DLS, TGA, TEM, and cryo-TEM as well as flow cytometry. The glyc..View full abstract
Awarded by German Federal Ministry of Economics and Technology
We thank the Dutch Polymer Institute (DPI, Technologic Area HTE) and the German Federal Ministry of Economics and Technology (Contract Number VF080018) for financial support.