Journal article

Functionalized, Biocompatible Coating for Superparamagnetic Nanoparticles by Controlled Polymerization of a Thioglycosidic Monomer

Krzysztof Babiuch, Ralf Wyrwa, Kerstin Wagner, Thomas Seemann, Stephanie Hoeppener, C Remzi Becer, Ralf Linke, Michael Gottschaldt, Juergen Weisser, Matthias Schnabelrauch, Ulrich S Schubert



It is demonstrated that water-soluble, glucosylated poly(pentafluorostyrene) derivatives revealed favorable coating material properties for magnetic iron oxide nanoparticles. To prepare the coating material in high reproducibility and purity as well as in sufficient amounts, a new route of synthesis is established. The preparation and characterization of the glucosylated, tetrafluorostyryl monomer, by thiol-para-fluorine "click" reaction, and its polymerization, via nitroxide-mediated radical process, is presented in detail. In addition, the coating material and the resulting particle properties are investigated by means of XPS, DLS, TGA, TEM, and cryo-TEM as well as flow cytometry. The glyc..

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University of Melbourne Researchers