Journal article

Longitudinal Systolic Blood Pressure Characteristics and Integrity of White Matter Tracts in a Cohort of Very Old Black and White Adults

Caterina Rosano, Kaleab Z Abebe, Howard J Aizenstein, Robert Boudreau, J Richard Jennings, Vijay Venkatraman, Tamara B Harris, Kristine Yaffe, Suzanne Satterfield, Anne B Newman

AMERICAN JOURNAL OF HYPERTENSION | OXFORD UNIV PRESS | Published : 2015

Abstract

BACKGROUND: We sought to determine which systolic blood pressure (SBP) characteristics are associated with reduced brain integrity and whether these associations are stronger for white or gray matter. We hypothesized that exposure to higher and variable SBP will be associated with lower structural integrity of both gray and white matter. METHODS: Neuroimaging, SBP, and cognition were obtained in 311 community-dwelling adults in 2006-2008 (average age = 83 years; 58% women; 40% black). Antihypertensive medications, SBP, and health-related factors were collected from 1997 to 1998 to time of neuroimaging. SBP values obtained from 1997 to 1998 to time of neuroimaging were used to compute mean; p..

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University of Melbourne Researchers

Grants

Awarded by National Institute on Aging (NIA)


Awarded by NIA


Awarded by National Institute of Nursing Research


Awarded by NATIONAL INSTITUTE OF NURSING RESEARCH


Awarded by NATIONAL INSTITUTE ON AGING


Funding Acknowledgements

We would like to acknowledge Lewis Lipsitz for his expert advice, Zachary Marcum with assistance with the medication inventory, and Amy J. Markowitz, JD, for her assistance in editing of the manuscript. This work was supported by National Institute on Aging (NIA) contracts N01 AG62101, N01 AG62103, and N01 AG62106; NIA grants R01 AG29232, R01 AG037451, and R01 AG028050; and National Institute of Nursing Research grant NR012459; and in part by the Intramural Research Program of the NIA, National Institutes of Health.