Journal article

Brain network changes and memory decline in aging

Lori L Beason-Held, Timothy J Hohman, Vijay Venkatraman, Yang An, Susan M Resnick

BRAIN IMAGING AND BEHAVIOR | SPRINGER | Published : 2017

Abstract

One theory of age-related cognitive decline proposes that changes within the default mode network (DMN) of the brain impact the ability to successfully perform cognitive operations. To investigate this theory, we examined functional covariance within brain networks using regional cerebral blood flow data, measured by 15O-water PET, from 99 participants (mean baseline age 68.6 ± 7.5) in the Baltimore Longitudinal Study of Aging collected over a 7.4 year period. The sample was divided in tertiles based on longitudinal performance on a verbal recognition memory task administered during scanning, and functional covariance was compared between the upper (improvers) and lower (decliners) tertile g..

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University of Melbourne Researchers