Brain network changes and memory decline in aging
Lori L Beason-Held, Timothy J Hohman, Vijay Venkatraman, Yang An, Susan M Resnick
BRAIN IMAGING AND BEHAVIOR | SPRINGER | Published : 2017
One theory of age-related cognitive decline proposes that changes within the default mode network (DMN) of the brain impact the ability to successfully perform cognitive operations. To investigate this theory, we examined functional covariance within brain networks using regional cerebral blood flow data, measured by 15O-water PET, from 99 participants (mean baseline age 68.6 ± 7.5) in the Baltimore Longitudinal Study of Aging collected over a 7.4 year period. The sample was divided in tertiles based on longitudinal performance on a verbal recognition memory task administered during scanning, and functional covariance was compared between the upper (improvers) and lower (decliners) tertile g..View full abstract
Awarded by Intramural Research Program of the NIH, National Institute on Aging and by Research and Development
Awarded by NATIONAL INSTITUTE ON AGING
This research was supported in part by the Intramural Research Program of the NIH, National Institute on Aging and by Research and Development Contract N01-AG-3-2124.