Peripheral sphingolipids are associated with variation in white matter microstructure in older adults
Christopher E Gonzalez, Vijay K Venkatraman, Yang An, Bennett A Landman, Christos Davatzikos, Veera Venkata Ratnam Bandaru, Norman J Haughey, Luigi Ferrucci, Michelle M Mielke, Susan M Resnick
NEUROBIOLOGY OF AGING | ELSEVIER SCIENCE INC | Published : 2016
Sphingolipids serve important structural and functional roles in cellular membranes and myelin sheaths. Plasma sphingolipids have been shown to predict cognitive decline and Alzheimer's disease. However, the association between plasma sphingolipid levels and brain white matter (WM) microstructure has not been examined. We investigated whether plasma sphingolipids (ceramides and sphingomyelins) were associated with magnetic resonance imaging-based diffusion measures, fractional anisotropy (FA), and mean diffusivity, 10.5 years later in 17 WM regions of 150 cognitively normal adults (mean age 67.2). Elevated ceramide species (C20:0, C22:0, C22:1, and C24:1) were associated with lower FA in mul..View full abstract
Awarded by National Institutes of Health/National Institute on Aging
Awarded by NATIONAL INSTITUTE ON AGING
This research was supported by a grant from the National Institutes of Health/National Institute on Aging (U01 AG37526) and by the Intramural Research Program of the National Institute on Aging, NIH.