Journal article
Sleep duration and subsequent cortical thinning in cognitively normal older adults
AP Spira, CE Gonzalez, VK Venkatraman, MN Wu, J Pacheco, EM Simonsick, L Ferrucci, SM Resnick
Sleep | OXFORD UNIV PRESS INC | Published : 2016
DOI: 10.5665/sleep.5768
Abstract
Study Objectives: To determine the association between self-reported sleep duration and cortical thinning among older adults. Methods: We studied 122 cognitively normal participants in the Baltimore Longitudinal Study of Aging with a mean age = 66.6 y (range, 51 84) at baseline sleep assessment and 69.5 y (range, 56 86) at initial magnetic resonance imaging (MRI) scan. Participants reported average sleep duration and completed a mean of 7.6 1.5-T MRI scans (range, 3 11), with mean follow-up from initial scan of 8.0 y (range, 2.0 11.8). Results: In analyses adjusted for age, sex, education, race, and interval between sleep assessment and initial MRI scan, participants reporting > 7 h sleep at..
View full abstractGrants
Awarded by National Institutes of Health
Funding Acknowledgements
This study was supported in part by the Intramural Research Program (IRP), National Institute on Aging (NIA), National Institutes of Health (NIH) and by Research and Development Contract HHSN-260-2004-00012C. Dr. Spira was supported in part by 1K01AG033195 and by 1R01AG050507 from the National Institute on Aging and has received funding from the William and Ella Owens Medical Research Foundation. Investigators from the NIH, NIA, and IRP were involved in all aspects of this manuscript, including the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Dr. Resnick has an immediate family member who has received grant/research support from Takeda, Roche, Pfizer, Lundbeck, Johnson & Johnson, Intracellular, GE Healthcare, DART Neuroscience, Avid/Lilly, and Piramal Imaging. The other authors report no conflicts of interest. Results from this study were presented at the 2015 Annual Meeting of the Gerontological Society of America.