Journal article
Lower gray matter integrity is associated with greater lap time variation in high-functioning older adults
Q Tian, SM Resnick, BA Landman, Y Huo, VK Venkatraman, CE Gonzalez, EM Simonsick, MD Shardell, L Ferrucci, SA Studenski
Experimental Gerontology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2016
Abstract
Background: Lower integrity of cerebral gray matter is associated with higher gait variability. It is not known whether gray matter integrity is associated with higher lap time variation (LTV), a clinically accessible measure of gait variability, high levels of which have been associated with mortality. This study examines the cross-sectional association between gray matter mean diffusivity (MD) and LTV in community-dwelling older adults. Methods: Study participants consisted of 449 high-functioning adults aged 50 and older (56.8% female) in the Baltimore Longitudinal Study of Aging, free of overt neurological disease. The magnitude of MD in the gray matter, a measure of impaired tissue inte..
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Awarded by National Institutes of Health
Funding Acknowledgements
This research was supported by the Intramural Research Program of the National Institute on Aging (grant number: 03-AG-0325). The authors would like to acknowledge the editorial assistance from the National Institutes of Health Fellows Editorial Board.