The effect of age and microstructural white matter integrity on lap time variation and fast-paced walking speed
Qu Tian, Luigi Ferrucci, Susan M Resnick, Eleanor M Simonsick, Michelle D Shardell, Bennett A Landman, Vijay K Venkatraman, Christopher E Gonzalez, Stephanie A Studenski
BRAIN IMAGING AND BEHAVIOR | SPRINGER | Published : 2016
Macrostructural white matter damage (WMD) is associated with less uniform and slower walking in older adults. The effect of age and subclinical microstructural WM degeneration (a potentially earlier phase of WM ischemic damage) on walking patterns and speed is less clear. This study examines the effect of age on the associations of regional microstructural WM integrity with walking variability and speed, independent of macrostructural WMD. This study involved 493 participants (n = 51 young; n = 209 young-old; n = 233 old-old) from the Baltimore Longitudinal Study of Aging. All completed a 400-meter walk test and underwent a concurrent brain MRI with diffusion tensor imaging. Microstructural ..View full abstract
Awarded by NATIONAL INSTITUTE ON AGING
This research was supported by the Intramural Research Program of the National Institute on Aging. Authors would like to thank the National Institutes of Health Editorial Fellows Editorial Board.