Lower digit symbol substitution score in the oldest old is related to magnetization transfer and diffusion tensor imaging of the white matter
Vijay K Venkatraman, Howard J Aizenstein, Anne B Newman, Kristine Yaffe, Tamara Harris, Stephen Kritchevsky, Hilsa N Ayonayon, Caterina Rosano
FRONTIERS IN AGING NEUROSCIENCE | FRONTIERS RESEARCH FOUNDATION | Published : 2011
BACKGROUND: Slowing information processing is common among community-dwelling elderly and it predicts greater mortality and disability risk. Slowing information processing is related to brain macro-structural abnormalities. Specifically, greater global atrophy and greater small vessel disease of the white matter (WM) have been associated with slower processing speed. However, community-dwelling elderly with such macro-structural abnormalities can maintain processing speed. The roles of brain micro-structure for slow processing in very old adults living in the community is uncertain, as epidemiological studies relating these brain markers to cognition and in the context of other health charac..View full abstract
Awarded by Intramural Research Program of the NIH, National Institute on Aging
Awarded by NATIONAL INSTITUTE ON AGING
N01-AG-6-2101, N01-AG-6-2103, N01-AG-6-2106. This research was supported in part by the Intramural Research Program of the NIH, National Institute on Aging. K23 AG 028966, R01 AG 029232.