Journal article

Lower digit symbol substitution score in the oldest old is related to magnetization transfer and diffusion tensor imaging of the white matter

Vijay K Venkatraman, Howard J Aizenstein, Anne B Newman, Kristine Yaffe, Tamara Harris, Stephen Kritchevsky, Hilsa N Ayonayon, Caterina Rosano

FRONTIERS IN AGING NEUROSCIENCE | FRONTIERS RESEARCH FOUNDATION | Published : 2011

Abstract

BACKGROUND: Slowing information processing is common among community-dwelling elderly and it predicts greater mortality and disability risk. Slowing information processing is related to brain macro-structural abnormalities. Specifically, greater global atrophy and greater small vessel disease of the white matter (WM) have been associated with slower processing speed. However, community-dwelling elderly with such macro-structural abnormalities can maintain processing speed. The roles of brain micro-structure for slow processing in very old adults living in the community is uncertain, as epidemiological studies relating these brain markers to cognition and in the context of other health charac..

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University of Melbourne Researchers

Grants

Awarded by Intramural Research Program of the NIH, National Institute on Aging



Awarded by NATIONAL INSTITUTE ON AGING


Funding Acknowledgements

N01-AG-6-2101, N01-AG-6-2103, N01-AG-6-2106. This research was supported in part by the Intramural Research Program of the NIH, National Institute on Aging. K23 AG 028966, R01 AG 029232.