Journal article

Executive control function, brain activation and white matter hyperintensities in older adults

Vijay K Venkatraman, Howard Aizenstein, Jack Guralnik, Anne B Newman, Nancy W Glynn, Christopher Taylor, Stephanie Studenski, Lenore Launer, Marco Pahor, Jeff Williamson, Caterina Rosano

NEUROIMAGE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2010

Abstract

CONTEXT: Older adults responding to executive control function (ECF) tasks show greater brain activation on functional MRI (fMRI). It is not clear whether greater fMRI activation indicates a strategy to compensate for underlying brain structural abnormalities while maintaining higher performance. OBJECTIVE: To identify the patterns of fMRI activation in relationship with ECF performance and with brain structural abnormalities. DESIGN: Cross-sectional analysis. MAIN VARIABLES OF INTEREST: fMRI activation, accuracy while performing an ECF task (Digit Symbol Substitution Test), and volume of white matter hyperintensities and of total brain atrophy. SETTING: Cohort of community-dwelling older ad..

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University of Melbourne Researchers

Grants

Awarded by National Institute of Aging


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Awarded by NATIONAL INSTITUTE ON AGING


Funding Acknowledgements

The authors thank P. Vincent, P. Kost, P. Varlashkin and S. Urda, for assistance in obtaining the data necessary for this analysis. This work is supported in part by the Intramural Research Program, National Institute of Aging (NIA 263-MA-706016).