Altered Striatal Response to Reward in Bulimia Nervosa After Recovery
Angela Wagner, Howard Aizenstein, Vijay K Venkatraman, Amanda Bischoff-Grethe, Julie Fudge, J Christopher May, Guido K Frank, Ursula F Bailer, Lone Fischer, Karen Putnam, Walter H Kaye
INTERNATIONAL JOURNAL OF EATING DISORDERS | WILEY | Published : 2010
OBJECTIVE: It is possible that disturbances of systems modulating reward may contribute to a vulnerability to develop an eating disorder. METHOD: This hypothesis was tested by assessing functional magnetic resonance brain imaging response to a monetary reward task known to activate the anterior ventral striatum (AVS), a region implicated in motivational aspects toward stimuli. To avoid the confounding effects of malnutrition, 10 women who had recovered from bulimia nervosa (BN) were compared with 10 healthy comparison women (CW). RESULTS: For the AVS, CW distinguished positive and negative feedback, whereas recovered BN women had similar responses to both conditions. In addition, these group..View full abstract
Awarded by National Institute of Mental Health (NIMH)
Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH
Supported by MH46001, MH42984, K05-MD01894, National Institute of Mental Health (NIMH), and by T32-MH18399 from NIMH Training Grant, and by the Price Foundation.