Journal article
Radiological evolution of porcine neurocysticercosis after combined antiparasitic treatment with praziquantel and albendazole
C Cangalaya, JA Bustos, J Calcina, A Vargas-Calla, J Mamani, D Suarez, G Arroyo, AE Gonzalez, J Chacaltana, C Guerra-Giraldez, S Mahanty, TE Nash, HH García
Plos Neglected Tropical Diseases | PUBLIC LIBRARY SCIENCE | Published : 2017
Abstract
Background: The onset of anthelmintic treatment of neurocysticercosis (NCC) provokes an acute immune response of the host, which in human cases is associated with exacerbation of neurological symptoms. This inflammation can occur at the first days of therapy. So, changes in the brain cysts appearance may be detected by medical imaging. We evaluated radiological changes in the appearance of brain cysts (enhancement and size) on days two and five after the onset of antiparasitic treatment using naturally infected pigs as a model for human NCC. Methods and results: Contrast T1-weighted magnetic resonance imaging with gadolinium was performed before and after antiparasitic treatment. Eight NCC-i..
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Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
This work was supported in part by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases, and by FIG-NIH training grant TW001140, NIH 1R01AI116456, and Beca Anual de Medicina "Francisco Tejada y Semiramis Reategui" 2014 Universidad Peruana Cayetano Heredia. HHG is supported by a Wellcome Trust Senior International Research Fellowship in Public Health and Tropical Medicine. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.