Immunogenicity of infectious pathogens and vaccine antigens
Siddhartha Mahanty, Antoine Prigent, Olivier Garraud
BMC Immunology | BMC | Published : 2015
The concept of the immunogenicity of an antigen is frequently encountered in the context of vaccine development, an area of intense interest currently due to the emergence or re-emergence of infectious pathogens with the potential for worldwide spread. However, the theoretical notion of immunogenicity as discussed in older textbooks of immunology needs reconsideration due to advances in our understanding of immunologic responses. Immunogenicity is a property that can either be a desirable attribute, for example in the generation of an effective protective immunity against infectious pathogens or an undesirable trait, for example when it relates to novel therapeutic compounds and drugs, where..View full abstract
This research was supported in part by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases, NIH.