Journal article

Neurocysticercosis: A natural human model of epileptogenesis

Theodore E Nash, Siddhartha Mahanty, Jeffrey A Loeb, William H Theodore, Alon Friedman, Josemir W Sander, Gagandeep Singh, Esper Cavalheiro, Oscar H Del Brutto, Osvaldo M Takayanagui, Agnes Fleury, Manuela Verastegui, Pierre-Marie Preux, Silvia Montano, E Javier Pretell, A Clinton White, Armando E Gonzales, Robert H Gilman, Hector H Garcia

EPILEPSIA | WILEY | Published : 2015

Abstract

OBJECTIVE: To develop a better understanding of mechanisms of seizures and long-term epileptogenesis using neurocysticercosis. METHODS: A workshop was held bringing together experts in epilepsy and epileptogenesis and neurocysticercosis. RESULTS: Human neurocysticercosis and parallel animal models offer a unique opportunity to understand basic mechanisms of seizures. Inflammatory responses to degenerating forms and later-stage calcified parasite granulomas are associated with seizures and epilepsy. Other mechanisms may also be involved in epileptogenesis. SIGNIFICANCE: Naturally occurring brain infections with neurocysticercosis offer a unique opportunity to develop treatments for one of the..

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University of Melbourne Researchers

Grants

Awarded by Fogarty International Center Training Grant from the National Institutes of Health


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE


Funding Acknowledgements

Supported in part by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases, the Office of Rare Diseases Research, the National Center for Advancing Translational Sciences, and Fogarty International Center Training Grant D43 TW00114, all from the National Institutes of Health. H.G. is supported by a Wellcome Trust Senior International Research Fellowship in Tropical Medicine and Public Health.