Journal article

CYTOKINE CONTROL OF PARASITE-SPECIFIC ANERGY IN HUMAN LYMPHATIC FILARIASIS - PREFERENTIAL INDUCTION OF A REGULATORY T-HELPER TYPE-2 LYMPHOCYTE SUBSET

CL KING, S MAHANTY, V KUMARASWAMI, JS ABRAMS, J REGUNATHAN, K JAYARAMAN, EA OTTESEN, TB NUTMAN

JOURNAL OF CLINICAL INVESTIGATION | ROCKEFELLER UNIV PRESS | Published : 1993

Abstract

The immunological mechanisms involved in maintenance of an asymptomatic microfilaremic state (MF) in patients with lymphatic filariasis remain undefined. MF patients have impaired filarial antigen (Ag)-specific lymphocyte proliferation and decreased frequencies (Fo) of Ag-specific T cells, and yet elevated serum IgE and antifilarial IgG4. To investigate the mechanism of Ag-specific anergy in MF patients in contrast to amicrofilaremic individuals with chronic lymphatic obstruction (CP), the Fo of Ag-specific lymphocytes from peripheral blood mononuclear cells secreting either IL-4 or IFN-gamma were assessed by filter spot enzyme-linked immunosorbent assay, and IL-10 and transforming growth fa..

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