Polymyxin-Induced Lipid A Deacylation in Pseudomonas aeruginosa Perturbs Polymyxin Penetration and Confers High-Level Resistance
Mei-Ling Han, Tony Velkov, Yan Zhu, Kade D Roberts, Anton P Le Brun, Seong Hoong Chow, Alina D Gutu, Samuel M Moskowitz, Hsin-Hui Shen, Jian Li
ACS Chemical Biology | AMER CHEMICAL SOC | Published : 2018
Awarded by National Institute of Allergy and Infectious Diseases of the National Institutes of Health
Awarded by ANSTO
This research was supported by a research grant from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (R01 AI111965, J.L. and T.V.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Allergy and Infectious Diseases or the National Institutes of Health. J.L. is an Australian National Health and Medical Research Council (NHMRC) Senior Research Fellow. H.-H.S. and T.V. are Australian NHMRC Career Development Research Fellows. The authors would like to thank AINSE and ANSTO for the financial assistance (awards of neutron beam time, P4787 and P5344; AINSE-PGRA). The authors are also grateful to Dr Darren Creek for technical assistance with the Liquid Chromatography-Mass Spectrometry instrument.