Journal article
The inhibitory effects of eighteen front-line antibiotics on the substrate uptake mediated by human Organic anion/cation transporters, Organic anion transporting polypeptides and Oligopeptide transporters in in vitro models
X Lu, T Chan, L Zhu, X Bao, T Velkov, QT Zhou, J Li, HK Chan, F Zhou
European Journal of Pharmaceutical Sciences | ELSEVIER SCIENCE BV | Published : 2018
Abstract
Human Organic anion/cation transporters (OATs/OCTs), Organic anion transporting polypeptides (OATPs) and proton-coupled Oligopeptide transporters (PepTs) are important membrane transporters responsible of the cellular influx of drugs in many human key tissues. Inhibitor(s) impacting on the cellular uptake of transporter drug substrates is one of the primary causes of drug-drug interactions that lead to unsatisfied therapeutic outcomes and/or unwanted side effects. In the current study, we selected eighteen antibiotic agents used in infectious disease treatment and comprehensively evaluated their inhibitory effects on the substrate uptake mediated through the essential OATs/OCTs, OATPs and Pe..
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Awarded by National Institutes of Health
Funding Acknowledgements
J.L., F.Z., Q.T.Z., K.C. and T.V. are supported by the Australian National Health and Medical Research Council (NHMRC, Grant ID 1104581). J.L. is an NHMRC Senior Research Fellow and T.V. is an NHMRC Career Development Fellow. J.L. and T.V. are also supported by the funding from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (R01 AI111965). X.B. is supported by National Natural Science Foundation of China (Grant ID: 31370209 and 31400165). The authors are solely responsible for the content, which does not necessarily represent the official views of the National Institute of Allergy and Infectious Diseases or the National Institutes of Health.