An "Unlikely" Pair: The Antimicrobial Synergy of Polymyxin B in Combination with the Cystic Fibrosis Transmembrane Conductance Regulator Drugs KALYDECO and ORKAMBI
Elena K Schneider, Mohammad AK Azad, Mei-Ling Han, Qi Tony Zhou, Jiping Wang, Johnny X Huang, Matthew A Cooper, Yohei Doi, Mark A Baker, Phillip J Bergen, Mark T Muller, Jian Li, Tony Velkov
ACS Infectious Diseases | AMER CHEMICAL SOC | Published : 2016
Awarded by National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health
Awarded by NIAID
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
We are grateful to Professor John Turnidge from the University of Adelaide for allowing us to reproduce some of the data in Supplementary Table 1 that were generated in his laboratory and previously reported.<SUP>23</SUP> We also are thankful for the CW-P. aeruginosa clinical strains obtained from Prof. Anton Y. Peleg and A/Prof. Denis Spelman from the Alfred Hospital, Melbourne, and the B. pseudomallei isolates provided by Professor Bart Currie (Menzies School of Health Research). This study is supported by a research grant to J.L. and T.V. from the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (R01AI111965). J.L. is an Australian National Health and Medical Research Council (NHMRC) Senior Research Fellow, and T.V. is an Australian NHMRC Industry Career Development Level 2 Research Fellow. E.K.S. acknowledges support from the U.S. Cystic Fibrosis Foundation. Y.D. acknowledges support from the NIAID (R01AI104895).