Journal article

Antibacterial low molecular weight cationic polymers: dissecting the contribution of hydrophobicity, chain length and charge to activity

James L Grace, Johnny X Huang, Soon-Ee Cheah, Nghia P Truong, Matthew A Cooper, Jian Li, Thomas P Davis, John F Quinn, Tony Velkov, Michael R Whittaker

RSC ADVANCES | ROYAL SOC CHEMISTRY | Published : 2016

Abstract

The balance of cationicity and hydrophobicity can profoundly affect the performance of antimicrobial polymers. To this end a library of 24 cationic polymers with uniquely low degrees of polymerization was synthesized via Cu(0)-mediated polymerization, using three different cationic monomers and two initiators: providing two different hydrocarbon chain tail lengths (C2 and C12). The polymers exhibited structure-dependent antibacterial activity when tested against a selection of bacteria, viz, Staphylococcus aureus ATCC 29213, Klebsiella pneumoniae ATCC 13883, Acinetobacter baumannii ATCC 19606, and Pseudomonas aeruginosa ATCC 27853 as a representative palette of Gram-positive and Gram-negativ..

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University of Melbourne Researchers

Grants

Awarded by Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology


Awarded by National Institute of Allergy and Infectious Diseases of the National Institutes of Health


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Funding Acknowledgements

This collaborative research was conducted by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036). TPD wishes to acknowledge the award of an Australian Laureate Fellowship. Jian Li and Tony Velkov are supported by a research grant from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (R01AI098771). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Allergy and Infectious Diseases or the National Institutes of Health. Jian Li is an Australian NHMRC Senior Research Fellow. Tony Velkov is an Australian NHMRC Industry Career Development Research Fellow.