Journal article

Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead

Tony Velkov, Nusaibah Abdul Rahim, Qi Tony Zhou, Hak-Kim Chan, Jian Li

ADVANCED DRUG DELIVERY REVIEWS | ELSEVIER SCIENCE BV | Published : 2015

Abstract

One of the most common causes of illnesses in humans is from respiratory tract infections caused by bacterial, viral or fungal pathogens. Inhaled anti-infective drugs are crucial for the prophylaxis and treatment of respiratory tract infections. The benefit of anti-infective drug delivery via inhalation is that it affords delivery of sufficient therapeutic dosages directly to the primary site of infection, while minimizing the risks of systemic toxicity or avoiding potential suboptimal pharmacokinetics/pharmacodynamics associated with systemic drug exposure. This review provides an up-to-date treatise of approved and novel developmental inhaled anti-infective agents, with particular attentio..

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University of Melbourne Researchers

Grants

Awarded by National Institute of Allergy and Infectious Diseases of the National Institutes of Health


Awarded by Australian National Health and Medical Research Council (NHMRC)


Awarded by NHMRC Project


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Funding Acknowledgements

The authors declare no competing financial or otherwise conflicts of interest with respect to the content of this review. J.L. and T.V. are supported by research grants from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (R01 AI098771 and All 11965). J.L. and T.V. are also supported by the Australian National Health and Medical Research Council (NHMRC, APP1026109). H.K.C., Q.T.Z. and J.L. acknowledge the financial support from NHMRC Project Grant funding scheme (APP1065046). J.L. is an Australian NHMRC Senior Research Fellow. T.V. is an Australian NHMRC Industry Career Development Research Fellow. Q.T.Z. is an Australian NHMRC Early Career Research Fellow. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Allergy and Infectious Diseases or the National Institutes of Health.