PK/PD models in antibacterial development
Tony Velkov, Phillip J Bergen, Jaime Lora-Tamayo, Cornelia B Landersdorfer, Jian Li
CURRENT OPINION IN MICROBIOLOGY | CURRENT BIOLOGY LTD | Published : 2013
There is an urgent need for novel antibiotics to treat life-threatening infections caused by bacterial 'superbugs'. Validated in vitro pharmacokinetic/pharmacodynamic (PK/PD) and animal infection models have been employed to identify the most predictive PK/PD indices and serve as key tools in the antibiotic development process. The results obtained can be utilized for optimizing study designs in order to minimize the cost and duration of clinical trials. This review outlines the key in vitro PK/PD and animal infection models which have been extensively used in antibiotic discovery and development. These models have shown great potential in accelerating drug development programs and will cont..View full abstract
Awarded by National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH)
Awarded by Instituto de Salud Carlos III
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
JL and TV are supported by Award Numbers R01 AI098771 from the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Allergy and Infectious Diseases or the National Institutes of Health. JL is an Australian National Health and Medical Research Council (NHMRC) Senior Research Fellow and TV is an NHMRC Industry Career Development Award Fellow. JL-T is supported by a grant from the Instituto de Salud Carlos III [FI09/00943] and by a travel grant from the Universidad de Barcelona.