Journal article

Reduced Frequencies and Heightened CD103 Expression among Virus-Induced CD8( ) T Cells in the Respiratory Tract Airways of Vitamin A-Deficient Mice

Rajeev Rudraraju, Sherri L Surman, Bart G Jones, Robert Sealy, David L Woodland, Julia L Hurwitz

CLINICAL AND VACCINE IMMUNOLOGY | AMER SOC MICROBIOLOGY | Published : 2012

Abstract

Vitamin A deficiency (VAD) has profound effects on immune responses in the gut, but its effect on other mucosal responses is less well understood. Sendai virus (SeV) is a candidate human parainfluenza virus type 1 (hPIV-1) vaccine and a candidate vaccine vector for other respiratory viruses. A single intranasal dose of SeV elicits a protective immune response against hPIV-1 within days after vaccination. To define the effect of VAD on acute responses toward SeV, we monitored both antibodies and CD8(+) T cells in mice. On day 10 following SeV infection, there was a trend toward lower antibody activities in the nasal washes of VAD mice than in those of controls, while bronchoalveolar lavage (B..

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University of Melbourne Researchers