Journal article

Phenotypes and functions of persistent Sendai virus-induced antibody forming cells and CD8( ) T cells in diffuse nasal-associated lymphoid tissue typify lymphocyte responses of the gut

Rajeev Rudraraju, Sherri Surman, Bart Jones, Robert Sealy, David L Woodland, Julia L Hurwitz

VIROLOGY | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2011

Abstract

Lymphocytes of the diffuse nasal-associated lymphoid tissue (d-NALT) are uniquely positioned to tackle respiratory pathogens at their point-of-entry, yet are rarely examined after intranasal (i.n.) vaccinations or infections. Here we evaluate an i.n. inoculation with Sendai virus (SeV) for elicitation of virus-specific antibody forming cells (AFCs) and CD8(+) T cells in the d-NALT. Virus-specific AFCs and CD8(+) T cells each appeared by day 7 after SeV inoculation and persisted for 8 months, explaining the long-sustained protection against respiratory virus challenge conferred by this vaccine. AFCs produced IgM, IgG1, IgG2a, IgG2b and IgA, while CD8+ T cells were cytolytic and produced low l..

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University of Melbourne Researchers