Journal article

Clonally Related CD8( ) T Cells Responsible for Rapid Population of Both Diffuse Nasal-Associated Lymphoid Tissue and Lung After Respiratory Virus Infection

Sherri L Surman, Rajeev Rudraraju, David L Woodland, Pradyot Dash, Paul G Thomas, Julia L Hurwitz

JOURNAL OF IMMUNOLOGY | AMER ASSOC IMMUNOLOGISTS | Published : 2011

Abstract

The immune system has evolved to use sophisticated mechanisms to recruit lymphocytes to sites of pathogen exposure. Trafficking pathways are precise. For example, lymphocytes that are primed by gut pathogens can, in some cases, be imprinted with CCR9 membrane receptors, which can influence migration to the small intestine. Currently, little is known about T cell trafficking to the upper respiratory tract or the relationship between effectors that migrate to the diffuse nasal-associated lymphoid tissue (d-NALT), the lower airways, and the lung. To determine whether a T cell primed by Ag from a respiratory pathogen is imprinted for exclusive trafficking to the upper or lower respiratory tract ..

View full abstract

University of Melbourne Researchers

Grants

Awarded by National Institutes of Health National Institute of Allergy and Infectious Diseases


Awarded by Center of Excellence for Influenza Research and Surveillance


Awarded by National Institutes of Health National Cancer Institute


Awarded by NATIONAL CANCER INSTITUTE


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Funding Acknowledgements

This work was supported in part by National Institutes of Health National Institute of Allergy and Infectious Diseases Grants P01 AI054955, R01 AI088729, R01 AI078819, and 5K22AI077714, Center of Excellence for Influenza Research and Surveillance Grant HHSN266200700005C, National Institutes of Health National Cancer Institute Grant P30 CA21765, and the American-Lebanese Syrian Associated Charities.