Journal article
Cortical Matrix Mineral Density Measured Noninvasively in Pre- and Postmenopausal Women and a Woman With Vitamin D–Dependent Rickets
CY Chiang, R Zebaze, XF Wang, A Ghasem-Zadeh, JD Zajac, E Seeman
Journal of Bone and Mineral Research | WILEY | Published : 2018
DOI: 10.1002/jbmr.3415
Abstract
Reduced bone mineral density (BMD) may be due to reduced mineralized bone matrix volume, incomplete secondary mineralization, or reduced primary mineralization. Because bone biopsy is invasive, we hypothesized that noninvasive image acquisition at high resolution can accurately quantify matrix mineral density (MMD). Quantification of MMD was confined to voxels attenuation photons above 80% of that produced by fully mineralized bone matrix because attenuation at this level is due to variation in mineralization, not porosity. To assess accuracy, 9 cadaveric distal radii were imaged at a voxel size of 82 microns using high-resolution peripheral quantitative computed tomography (HR-pQCT; XtremeC..
View full abstractGrants
Funding Acknowledgements
ES has received research support, lectured at national and international meeting symposia funded by Allergan, Amgen, Asahi, Genzyme, Merck Sharp & Dohme. He is a director of the board and shareholder in StraxCorp, is remunerated by StraxCorp as chief medical officer, and is one of the inventors of the StrAx1.0 algorithm. RZ has received grant and/or research support from Amgen, Merck Sharp & Dohme, Servier, Warner-Chilcott, AKP, Genzyme, Sanofi, GSK, and Pfizer. He is a shareholder in StraxCorp, is remunerated by Strax Corp as president of R&D, and is one of the inventors of the StrAx1.0 algorithm. RZ is also a director on the board of StraxCorp. CC has received grant and or research support from Amgen, Merck Sharp & Dohme, Servier and Sanofi. AG and JZ have nothing to declare.