Cost-Effectiveness of Treatments for the Management of Bone Metastases: A Systematic Literature Review

Abstract

Background: Metastatic cancers occur when cancer cells break away from the primary tumour. One of the most common sites of metastasis is the bone, with several therapeutic options currently available for managing bone metastases. In a resource-constrained environment, policy makers and practitioners need to know which options are cost effective. Objective: The aim of this systematic review was to review and appraise published economic evaluations on treatments for the management of bone metastases. Methods: We searched eight bibliographic databases (MEDLINE, MEDLINE in Process, EMBASE, CSDR, DARE, HTA, EED and CPCI) for relevant economic evaluations published from each database’s inception d..