Journal article

COMPARISON OF SERUM PROCOLLAGEN-III PEPTIDE CONCENTRATIONS AND PGA INDEX FOR ASSESSMENT OF HEPATIC-FIBROSIS

JP TEARE, D SHERMAN, SM GREENFIELD, J SIMPSON, G BRAY, AP CATTERALL, IM MURRAYLYON, TJ PETERS, R WILLIAMS, RPH THOMPSON

LANCET | LANCET LTD | Published : 1993

Abstract

In early hepatic fibrosis, increased amounts of type III collagen are deposited. Persistently high serum concentrations of aminoterminal type III procollagen propeptide (PIIIP) correlate with the activity of the fibrogenic process. Another index for the detection of fibrosis, the PGA index, combines the prothrombin time, gamma-glutamyl transpeptidase activity, and serum apolipoprotein A1 concentration (the latter falls with progressive fibrosis). We compared PIIIP measurements and PGA index in patients with various histological forms of alcoholic liver disease (104), primary biliary cirrhosis (38), and chronic B virus hepatitis (27), and in healthy age-matched controls (30). The ability of e..

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