Journal article

Renal Subcapsular Transplantation of PSC-Derived Kidney Organoids Induces Neo-vasculogenesis and Significant Glomerular and Tubular Maturation In Vivo

Cathelijne W van den Berg, Laila Ritsma, M Cristina Avramut, Loes E Wiersma, Bernard M van den Berg, Danielle G Leuning, Ellen Lievers, Marije Koning, Jessica M Vanslambrouck, Abraham J Koster, Sara E Howden, Minoru Takasato, Melissa H Little, Ton J Rabelink

Stem Cell Reports | CELL PRESS | Published : 2018

Grants

Awarded by European Community's Seventh Framework Program (FP7) (Stem cell-based therapy for kidney repair, STELLAR, grant)


Awarded by European Community's Seventh Framework Program RECellularizing ORgan Donors for KIDney bioengineering (RECORD KID, Dutch Kidney Foundation)


Awarded by NIH


Awarded by National Health and Medical Research Council (NHMRC)


Awarded by Veni-grant from the Netherlands Organisation for Scientific Research (NWO)


Awarded by Leids Universiteits Fonds (LUF)


Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Funding Acknowledgements

We thank Christian Freund (hiPSC core facility, LUMC, Leiden, the Netherlands) for providing two hiPSC lines (LUMC0072iCTRL01 and LUMC0099iCTRL04), Christine Mummery (LUMC, Leiden, the Netherlands) for providing hES3 ENVY, and Andrew Elefanty and Edouard Stanley (MCRI, Melbourne, Australia) for providing reporter hESC-SOX17-mCherry. We acknowledge the support of Maaike Hanegraaf, Angela Koudijs, Dorien Ward-van Oostwaard, Manon Zuurmond (LUMC, Leiden, the Netherlands), Caro Overmars-Bos and Joost Hoenderop (Radboud UMC, Nijmegen, the Netherlands), and Pei Er, Joanne Soo and Irene Ghobrial (MCRI, Melbourne, Australia). M.H.L. is a Senior Principal Research Fellow of the National Health and Medical Research Council of Australia (GNT1042093). Funding is from the European Community's Seventh Framework Program (FP7/2007-2013) (Stem cell-based therapy for kidney repair, STELLAR, grant agreement number 305436) and RECellularizing ORgan Donors for KIDney bioengineering (RECORD KID, Dutch Kidney Foundation, 15RN02), the NIH (DK107344), and the National Health and Medical Research Council (NHMRC, GNT1100970). C.W.v.d.B. is supported by the Wiyadharma fellowship (Bontius Stichting, LUMC). L.R. is supported by a Veni-grant from the Netherlands Organisation for Scientific Research (NWO, 016.176.081), the Gisela Thier grant (LUMC), and a subsidy from the Leids Universiteits Fonds (LUF, CWB 7204). MCRI is supported by the Victorian Government's Operational Infrastructure Support Program.