Is ‘gamma’ (40 Hz) synchronous activity disturbed in patients with traumatic brain injury?

Abstract

Objectives: The objective of this work is to determine whether Gamma (40Hz) synchronous activity has disturbed patients with severe traumatic brain injury (TBI). Methods: Using a conventional auditory oddball paradigm, the extent of Gamma synchrony across multiple scalp sites in specific frequency bands as a function of time was examined in 15 patients with severe TBI and 15 age- and sex-matched controls. Averaged Gamma synchrony was analyzed using within and betweengroup multiple analyses of variance with region (left versus right hemisphere, anterior versus posterior region) as the within factor. Results: Compared to controls, subjects with TBI displayed significantly delayed early Gamma l..