Conference Proceedings
Genomic analysis of cancers arising in breasts with different mammographic density
Kylie L Gorringe, Siobhan Hughes, Carolyn Nickson, Lisa Devereux, Vicki Pridmore, Simone M Rowley, David J Byrne, Dane Cheasley, Anne M Kavanagh, G Bruce Mann, Stephen B Fox, Ian G Campbell
CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2018
Abstract
Abstract Background: High mammographic density (MD) is a known risk factor for breast cancer, but it is currently unknown whether this altered microenvironment leads to the development of genomically different tumours. Method: We used lifepool, an Australian prospective population-based cohort of over 53,000 women currently in a mammographic screening program, to identify >1000 cases of breast carcinoma (in situ and invasive breast cancer) for analysis. Pathology reports, detection modality (screen-detected/interval), MD data (AutoDensity, Nickson et al., 2013 DOI:10.1186/bcr3474), germline DNA and tumor tissue were available for a subset of cases. Tumours we..
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