Journal article
CD4 recent thymic emigrants are recruited into granulomas during leishmania donovani infection but have limited capacity for cytokine production
JWJ Moore, L Beattie, M Osman, BMJ Owens, N Brown, JE Dalton, A Maroof, PM Kaye
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2016
Abstract
Recent thymic emigrants (RTEs) represent a source of antigen-naïve T cells that enter the periphery throughout life. However, whether RTEs contribute to the control of chronic parasitic infection and how their potential might be harnessed by therapeutic intervention is currently unclear. Here, we show that CD4+ recent thymic emigrants emerging into the periphery of mice with ongoing Leishmania donovani infection undergo partial activation and are recruited to sites of granulomatous inflammation. However, CD4+ RTEs displayed severely restricted differentiation either into IFNγ+ or IFNγ+TNFα+ effectors, or into IL-10-producing regulatory T cells. Effector cell differentiation in the chronicall..
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Awarded by Pathological Society of Great Britain and Ireland
Funding Acknowledgements
[ "This work was supported by grants to PMK from the UK Medical Research Council (http//www.mrc.ac.uk; G1000230). JWJM was supported by a PhD studentship award from the Pathological Society of Great Britain and Ireland (http://www.pathsoc.org) and BMJO was supported by a MRC Postgraduate Training Award. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.", "The authors thank the staff of the Biological Services Facility and the Technology Facility, University of York for their technical assistance. We are grateful to Mark Coles for helpful suggestions and for comments on the manuscript. JWJM was supported by a PhD studentship award from the Pathological Society of Great Britain and Ireland (http://www.pathsoc.org) and BMJO was supported by a MRC Postgraduate Training Award. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript." ]