The Neurotrophic Receptor Ntrk2 Directs Lymphoid Tissue Neovascularization during Leishmania donovani Infection
Jane E Dalton, Amy C Glover, Laura Hoodless, Eng-Kiat Lim, Lynette Beattie, Alun Kirby, Paul M Kaye
PLoS Pathogens | PUBLIC LIBRARY SCIENCE | Published : 2015
The neurotrophic tyrosine kinase receptor type 2 (Ntrk2, also known as TrkB) and its ligands brain derived neurotrophic factor (Bdnf), neurotrophin-4 (NT-4/5), and neurotrophin-3 (NT-3) are known primarily for their multiple effects on neuronal differentiation and survival. Here, we provide evidence that Ntrk2 plays a role in the pathologic remodeling of the spleen that accompanies chronic infection. We show that in Leishmania donovani-infected mice, Ntrk2 is aberrantly expressed on splenic endothelial cells and that new maturing blood vessels within the white pulp are intimately associated with F4/80(hi)CD11b(lo)CD11c(+) macrophages that express Bdnf and NT-4/5 and have pro-angiogenic poten..View full abstract
Awarded by UK Medical Research Council
Awarded by Medical Research Council
Funding: This study was supported by a grant from the UK Medical Research Council (http://www.mrc.ac.uk; G1000230 to PMK). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.