Journal article

IL-10-Producing Th1 Cells and Disease Progression Are Regulated by Distinct CD11c( ) Cell Populations during Visceral Leishmaniasis

Benjamin MJ Owens, Lynette Beattie, John WJ Moore, Najmeeyah Brown, Jason L Mann, Jane E Dalton, Asher Maroof, Paul M Kaye

PLoS Pathogens | PUBLIC LIBRARY SCIENCE | Published : 2012


IL-10 is a critical regulatory cytokine involved in the pathogenesis of visceral leishmaniasis caused by Leishmania donovani and clinical and experimental data indicate that disease progression is associated with expanded numbers of CD4⁺ IFNγ⁺ T cells committed to IL-10 production. Here, combining conditional cell-specific depletion with adoptive transfer, we demonstrate that only conventional CD11c(hi) DCs that produce both IL-10 and IL-27 are capable of inducing IL-10-producing Th1 cells in vivo. In contrast, CD11c(hi) as well as CD11c(int/lo) cells isolated from infected mice were capable of reversing the host protective effect of diphtheria toxin-mediated CD11c⁺ cell depletion. This was ..

View full abstract

University of Melbourne Researchers


Awarded by Medical Research Council

Funding Acknowledgements

This work was supported by grants (to P. M. K.) from the UK Medical Research Council ( and the Wellcome Trust ( and by a MRC Doctoral Training Award (to B.M.J.O.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.