Dendritic Cells Matured by Inflammation Induce CD86-Dependent Priming of Naive CD8( ) T Cells in the Absence of Their Cognate Peptide Antigen
Asher Maroof, Lynette Beattie, Alun Kirby, Mark Coles, Paul M Kaye
The Journal of Immunology | AMER ASSOC IMMUNOLOGISTS | Published : 2009
Dendritic cells (DC) licensed by the interaction between pathogen products and pattern recognition receptors can activate naive T cells to undergo Ag-dependent proliferation and cytokine production. In contrast, DC induced to mature by trans-acting inflammatory stimuli are believed to only be capable of supporting Ag-dependent proliferative responses. In this study, we show that uninfected DC matured as a consequence of Leishmania-induced inflammation induce CD8(+) T cells to proliferate in the absence of their cognate Ag. We separated splenic DC from Leishmania donovani-infected mice into those that contained parasites and had been activated to induce IL-12p40, from those that had undergone..View full abstract
Awarded by Medical Research Council
This work was supported by grants front the Wellcome Trust and the British Medical Research Council.